ABSTRACT
Introducción: La miositis aguda benigna infantil es una complicación transitoria de la gripe causada por los virus influenza A o B, observada en pacientes escolares. Objetivos: Contribuir a divulgar las características de la miositis aguda benigna infantil en el personal médico. Métodos: Investigación descriptiva transversal en 18 pacientes con edad inferior a 19 años atendidos con el diagnóstico de esta afección, en el Hospital Pediátrico Docente Cerro desde el primero de octubre hasta 31 de diciembre del 2019. Se tomó muestra de sangre para estudios hematológicos y enzimáticos, determinación de anticuerpos antidengue y exudado nasofaríngeo en busca de virus respiratorios. Se empleó el programa SSPS versión 19. Los resultados se expresaron en valores absolutos, porcentajes, y los del laboratorio clínico, en promedios y desviación estándar. Resultados: Predominó la edad de 5-14 años (88 por ciento), sexo masculino (72,2 por ciento) y residencia en los municipios Cerro y 10 de 0ctubre (55,5 y 22,2 por ciento), respectivamente. El tipo de marcha anormal más frecuente fue la Frankenstein, con un conteo leucocitario promedio de 7,01 × 109 ± 2,16; linfocitosis 53,3 por ciento y promedio de creatininfosfoquinasa 591 µl × L ± 435,74. Todos los pacientes se recuperaron. El virus influenza B se identificó en 77,7 por ciento de las muestras. Conclusiones: La miositis constituyó una complicación por los virus de la gripe en mayor proporción el tipo B, en pacientes varones escolares, que mostraron trastornos en la marcha, examen neurológico normal y creatininfosfoquinasa elevada. Todos los enfermos se recuperaron en los primeros tres días de iniciada la afección(AU)
Introduction: Children mild acute myositis is a transitory complication of the flu caused by the influenza A or B viruses which presents in school patients. Objectives: To contribute to spread the characteristics of children mild acute miositis in the medical staff. Methods: Descriptive cross-sectional research in 18 patients with ages under the 19 years that were attented with a diagnosis of the disease in "Cerro" Pediatric Teaching Hospital from October 1st to December 31st, 2019. There were taken blood samples to do enzymatic and hematologic studies, antidengue antibodies determination and nasopharinx exudates looking for respiratory viruses. SSPS version 19 program was used. The results were expressed in absolute values, percentages, averages and standard deviation. Results: There was predomiance of the ages from 5 to 14 years (88 percent), male sex (72.2 percent) and living in Cerro and 10 de octubre municipalities (55,5 percent and 22,2 percent, respectively). The most frquent type of abnormal walk was the Frankenstein with an average leukocytes count of 7.01 × 109 ± 2.16; lymphocytea of 53.3 percent; and an average of creatinine fosfoquinase 591 µl × L ± 435.74. All the patients recovered. The influenza B virus was identified in 77.7 percent of the samples. Conclusions: Myositis represented a complication by influenza viruses, mainly the type B, in school male patients who showed disorders in the walk, normal neurologic examination and high creatinine phosphokinase. All the patients recovered in the first 3 days after the onset of the disease(AU)
Subject(s)
Humans , Male , Female , Child , Adolescent , Influenza B virus/growth & development , Gait/physiology , Myositis/complications , Epidemiology, Descriptive , Cross-Sectional StudiesABSTRACT
Aims:Coagulation profile shows the clotting ability of blood. Biochemical tests indicate health status of vital organs such as liver, heart and kidneys. Herbal products are being assessed for their role in affecting these parameters. We evaluated role of Foeniculumvulgareincorporated diet on coagulation profile and some important biochemical parameters.Study Design:Laboratory centred randomized controlled trial.Place and Duration of Study: Pharmacology Department of University of Karachi, Karachi between June 2018 and September 2018 Methodology: After selecting 30 healthy rabbits of either sex, we placed them in three groups; Control, 2% Foeniculumvulgareand 4% Foeniculumvulgaregroup. Control group was given standard diet whereas; 2% and 4% Foeniculumvulgaregroups were maintained on standard diet containing 2% and 4% Foeniculumvulgarecrushed seeds. Coagulation profile and some biochemical parameters were done after interval of a month, for two months.Results:Platelet count and fibrinogen increased while activated partial thromboplastin time (APTT) levels decreased in both the study groups animals as compared to control, while blood urea nitrogen (BUN), creatinine phosphokinase (CPK) and lactate dehydrogenase (LDH) elevation was noted both Foeniculumvulgaregroups but within normal range.Conclusion:Foeniculumvulgaremay have some role in affecting coagulation and biochemical profile These parameters, however, need clinical trial to validate reliability
ABSTRACT
The present study was doen to investigate the reliability of maternal serum Creatinine Phosphokinase (CPK) in the diagnosis of ectopic pregnancy.100 consecutive women with documented tubal pregnancies (Group A) and 50 women with normal intra-uterine pregnancy (Group B) were prospectively studied. Women matched for age, gestational age and parity were included in both groups. Serum CPK levels of both groups were analyzed and plotted. The mean CPK levels in the study group (103 ± 50.3 IU/L) were significantly higher than the mean CPK levels of control group (52.4 ± 10.9 IU/L). The mean CPK levels in the study group showed gradual increment with increase in the gestational age, unlike the control group. The sensitivity and specificity of serum CPK level at 70 IU/L was 95% and 98% respectively. The positive predictive value was 99% and the negative predictive value 90.7% for the diagnosis of tubal pregnancy.Hence, serum CPK levels are significantly higher in women with tubal pregnancy that may or may not have ruptured and are reliable in the diagnosis of a tubal pregnancy.
ABSTRACT
El aumento prolongado de la transaminasa glutámico-pirúvica, sin causa demostrada de afectación hepática, o la elevación de los niveles de la creatina-cinasa en niños con pocos síntomas de trastorno neuromuscular o sin ellos, es motivo poco frecuente de consulta en neuropediatría. Se presenta un resumen de lo reportado al respecto en la literatura médica, y se incluyen comentarios al respecto y la propuesta de un algoritmo para el diagnóstico.
A lengthy increase of glutamic-pyruvic transaminase, without a proved cause, or rise of creatinine phosphokinase levels in children with a few symptoms of neuromuscular disorder or without them, is an infrequent reason of consultation in Neuropediatrics service. Authors present a summary of features reported in this respect in medical literature, and are included comments, as well as proposal of a algorithm for diagnosis.